Omnisphere 2 (O2) cannot and does not change anything to do witb your audio.... There is nothing in it's installation procedure that can do that...
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So...
If you are talking about all plugins not producing audio...
Have you checked that your audio device is still selected correctly under Logic's Prefs > Audio > Devices and also that Core Audio is still checked?
If you are refering to just O2 not producing any sound.. Have you correctly authorized Omni via the Spectrasonic's Website?
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If you haven't O2 will not produce sound...
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or..
No Sound In Omnisphere 2 Windows
If you are using an illegal copy of O2 then its not a surprise you had 'son much difficulty' during installation... and you should seek help elsewhere..
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Otherwise, contact Spectrasonics directly as they are using extremely helpful with such issues...